ENBIS-17 in Naples

9 – 14 September 2017; Naples (Italy) Abstract submission: 21 November 2016 – 10 May 2017

Understanding Migraine by Using a Digital Platform to Capture Daily Individual Prospective Data

12 September 2017, 15:10 – 15:30


Submitted by
Marina Vives-Mestres
Marina Vives-Mestres (Universitat de Girona), G. Boucher (Curelator Inc. Cambridge, Massachusetts), P. Pietro (Curelator Inc. Cambridge, Massachusetts), S. Donoghue (Curelator Inc. Cambridge, Massachusetts), A. Mian (Curelator Inc. Cambridge, Massachusetts)
Certain chronic diseases such as migraine result in episodic, debilitating attacks for which neither cause nor timing is well understood. Curelator HeadacheTM is a digital platform where, individual users record attacks and symptoms as well as their daily exposure to a list of more than 70 potential factors for 90 days. These factors (mood, stress, diet, activity etc.) may affect attack occurrence (1-3).

For each individual, univariate associations between factors and migraine events were analysed using Cox proportional hazards models. Results were validated against an existing database and study (4-6). The analysis of individual profiles (not aggregated data), helps users understand relevance and modify exposure to the factors associated with their own migraines.

The challenge now is to analyze the daily growing reported data to answer migraine related research questions leading to an improvement of population and individual health outcomes. Such questions include commonly believed associations with migraine occurrence or severity such as menstruation, mood (i.e. stress, anxiety) or dietary (i.e. tyramine, alcohol), migraine frequency pattern In this presentation we show some initial analytical advances together with new challenges to be faced. An open discussion with the audience is proposed.

(1) Spierings ELH et al. Curr Pain Headache Rep.2014;18:455 -- (2) Donoghue S et al. Cephalalgia.2015;35 (6S):40 -- (3) Donoghue S et al. Headache.2016;56(Supp 1):36;DOI:10.1111/head.12832 -- (4) Peris, F et al. Cephalagia.2016;37(5):452-463 -- (5) Salhofer-Polanyi S et al, Headache.2012;52(8):1236-45 -- (6) Wober C et al, Cephalalgia.2007;27(4):304-14

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